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Pritelivir is a new herpes treatment in clinical trials that is already proving to be more effective than valacyclovir

Could pritelivir be the latest entry in the race for a herpes treatment?  According to the Fred Hutchinson Cancer Research Center, the early clinical trials look very promising.  Mary Engel just published another excellent article in the field of new advances in finding a treatment/cure for herpes.  This time, she focuses on the German drug maker, AiCuris and their latest clinical trials on their new drug, pritelivir.

While still in the experimental stage, it is already proving to be more effective than valacyclovir (Valtrex) in its human trials according to the results published today.

The results of the phase 2, randomized, double-blind trial published today showed that when people with genital herpes took a daily oral dose of pritelivir, they reduced their rate of viral shedding by half compared to when they took valacyclovir. They also had fewer genital sores and less pain.

If pritelivir makes it to market, it would mean more options and competition.  Right now, the only prescription options to treat herpes are valacyclovir (Valtrex), acyclovir (Zovirax) and famciclovir (Famvir) with each one having its own side effects.  These drugs can be expensive and cost prohibitive, especially if you do not have insurance.  More than a few have stuttered the words, “How…How much??” as they stood at the counter trying to pay for their first prescription.  As new drugs hit the market, it will (Hopefully) drive the prices down. [click to continue…]

Can gene editing cure herpes?

Drs. Martine Aubert and Keith Jerome showed for the first time in a living organism that DNA-cutting enzymes called targeted endonucleases can be used to disrupt latent herpes simplex virus. Photo by Robert Hood / Fred Hutch News Service

We received an email from Mary Engel, a couple of weeks ago, asking if there was any interest in a cure for herpes for her upcoming article for the Fred Hutch Cancer Research Center. Naturally, we knew the answer was an easy, “Yes!'”.  Here is her article that has some really great information.  We reprinted it with permission.   At the bottom of the article is a link to Fred Hutch’s Facebook page so make sure to throw some likes their way. It sounds like they are doing some great work.  The original article can be found here.

Can gene editing cure herpes?

Fred Hutch study shows ‘pathway to potential cure’ for herpes simplex and other latent viruses
Sept. 8, 2016
| By Mary Engel / Fred Hutch News Service

Scientists at Fred Hutchinson Cancer Research Center have used a gene-editing technique to attack the DNA of the herpes simplex virus in infected mice, a key step on the road to defeating an often-stigmatized virus that infects one in six people in the United States alone and for which there is no cure.

The study, published today in the journal JCI Insight, “lays out the pathway toward a potential cure for human herpesvirus infections,” said Dr. Keith Jerome, a Fred Hutch and University of Washington virologist and the paper’s senior author.

Researchers in Jerome’s lab deployed DNA-cutting enzymes called targeted endonucleases to damage the herpesvirus genome, inducing mutations that destroy the virus’ ability to replicate. The study is the first in a living organism — rather than a lab dish — to show that gene-editing tools can be delivered to the herpes simplex virus in its latent state or to a latent viral infection of any kind. Doing so is key to curing herpes because a latent infection can reactivate and seed new outbreaks. [click to continue…]

Clinicial Trials for a HSV2 vaccine

Central Kentucky Research Associates in Lexington, KY is now enrolling volunteers for a clinical research trial of an investigational therapeutic vaccine for HSV-2

UPDATED 8/29/2016

If you live in or around Lexington, KY and want to take part of a clinical research trial for a HSV-2 vaccine, there are spots available!  Greta BonDurant from Central Kentucky Research Associates just reached out to us to get volunteers for their new trial.  Of, course, we are always happy to help.

Here is her email:

I am writing to let you know that Central Kentucky Research Associates in Lexington, KY is now enrolling volunteers for a clinical research trial of an investigational therapeutic vaccine for HSV-2.

We are looking for people between the ages of 18 and 50 who have had HSV-2 for at least 1 year and who have had between 4 and 9 recurrences over the past 12 months to participate. We wanted to reach out to the support groups in this area to make them aware of the study, so any help you can offer in terms of spreading the word about this important study to your members would be greatly appreciated!

If you have any questions or would like some more information, I can be reached at 859-264-8999 or at the email address provided.

Thank you in advance for your time!
Greta BonDurant

We asked her for a website because these pages get a lot of traffic and didn’t want her phone to go crazy.  She replied, quickly: [click to continue…]

testfbWe just opened a secret Facebook group!  Facebook has become wildly popular for their groups and especially for people with herpes.  There is an entire network of secret herpes Facebook groups already out there with 1000’s of members.  Some focus on support while others are regional, by state and even event related.

Just to clarify, once you are a member it is totally up to you if you want to join our Facebook group.  It was simply created as an option and the same rules of conduct of the site also apply in the group.  If you are still interested, read on!

You may be asking yourself why we would ever open up our own group when we already have an awesome community.  Just off the top of our heads, we came up with the four biggest ones.

Our Members – They asked for it and we delivered!  We really appreciate our members and listen to their wishes.  This gives them another line of communication with other members and access to other secret groups.  Since Facebook is so easily accessible, it is much easier to check your account at work with worrying about the IT guy seeing that you visited HWerks.  Many also prefer Facebook over the forums.  That brings us to our next point…

[click to continue…]

Herpes Testing

Theranos has released a sub $25 herpes test that is already out in select areas.

An easy to get and reliable herpes test for under $25?  If Theranos has it’s way, you may soon be able to walk into a local Walgreens and simply order one.

Getting tested isn’t always as easy as it should be.  Just the awkwardness of the, “I’m here for the herpes test” visit to the doctor is enough of a deterrent for many.  On top of that, there is the problem that most STD tests do NOT include a test for herpes.  Finally, throw in the expense of the test, exam and you have the prefect storm of people totally unaware they are carrying the herpes virus.  This just may be a thing of the past.

Theranos, an amalgam of “therapy” and “diagnosis,” was founded by college dropout, Elizabeth Holmes.  At just 31 years old, she is also the world’s youngest self-made female billionaire who is revolutionizing the lab testing industry by gearing its products directly to the consumer.

Right now, the majority of the Theranos Wellness Centers are located inside Walgreen locations in and around Phoenix, AZ with a couple in California and one in Pennsylvania.  They plan on opening more locations soon. [click to continue…]

MTV Herpes Show

MTV is looking for people living and dating with herpes for their new documentary series.

Are you living with herpes and dated someone off of a herpes dating site or found love from one?  Are you between the ages of 18-27?  If so, MTV wants to hear from you!

A producer from MTV emailed us a few days ago about their upcoming series which will focus on people with herpes, dating online and their story.  They are looking for individuals or couples right now.  From our conversation, this will be a serious series. Herpes is one of the last remaining medical conditions where is it still acceptable to be the butt of many jokes and MTV hopes to change this.  This holds especially true for the younger audience where new cases of herpes is skyrocketing.  This will be a great opportunity to not only tell your story but help educate others on what living with herpes and dating online is like from a personal perspective.

Here is what they are looking for:

New MTV web docu-series is looking for people like you

MTV is looking for people who have looked for love or found love using a herpes dating site to be interviewed for our new web series, premiering later this year. While 1 in 6 people in the United States has herpes, [click to continue…]