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Gen-003 heres treatment

Could a effective herpes treatment be close? Genocea’s GEN-003 entered Phase 2 in 2015

While a herpes cure may be a long way off, a herpes treatment may be getting closer.  A little over 2 years ago, we wrote about Genocea’s GEN-003 therapeutic vaccination. The good news is the study is still going on and Genocea has updated their website with some promising information.

First and foremost, Genocea’s GEN-003 is NOT a cure for herpes.  Instead, they are working on a herpes treatment for the symptoms of the genital herpes (HSV2) virus and the reduction of the spread of herpes through viral shedding.

Genocea:  GEN-003 is a first-in-class T cell-directed immunotherapy intended to reduce the transmission risk and clinical symptoms of genital herpes.

On Oct. 8, 2014, Genocea issued a press release stating that their Phase 1/2a clinical trial has been completed:

After 12 months, GEN-003 shows durable reduction in genital lesions

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HPV Epidemic –  “I wish the cancer would have killed you!” These are the chilling words of Susie’s husband when he learned that her cancer was caused by HPV, a sexually transmitted virus. Narrated by Vanessa Williams, this poignant documentary takes a look into the lives of five women affected by HPV, the widely misunderstood and controversial virus that causes several types of cancer, including cervical. Each of these women has an intimate story to tell. For Susie, Tamika and Christine, it’s a story of survivorship that comes with misconceptions, stigma, shame, heartbreak, pain and triumph. For the Forbes’ family, it’s about coping with the loss of their daughter Kristen and trying to prevent it from happening to others like her. Others like Kelly, who at 31 years began her cancer journey. The cameras follow Kelly on her epic battle to save her marriage, her career, her family and ultimately, her life.

The Human Papilloma Virus HPV may be the most widespread, misunderstood and potentially dangerous epidemic that most people hardly know anything about. 80 percent of all people under 50 years of age will have a strain of the virus at some point in their lives and most will not even realize they have it.

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The new look of HWerks

Herpes Dating really did get easier…and cheaper, too!

A New Look and a Bonus!! –  Big things have been happening over here at HWerks! 

Today, we updated the “Outside pages” of the site.  After a couple of years, the design was getting kind of tired and a little stale.  The new design is (We think!) more user friendly to the reader who is here looking for information.  While herpes dating is part of who we are, we also want to be a resource for those looking for answers.  There is a LOT of bad information out on the internet and we would like to steer then in the right direction.  We have already seen a rise in the comment sections on the blogs.

Membership is also up!  Sure, it does slow down a bit in the summer but since the temperature has started to drop we have been picking up.  It is always great to see the new members!

Speaking of membership, we can’t thank our members enough.  They really are the ones who make this place great.  Without them, we would just be website and not the awesome community that we are.

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Herpes Support

Living with herpes isn’t always easy!  Sometimes, a little support is all that’s needed to get you back on the right track.

 

Trying to find herpes support isn’t always easy. You almost need to live in major city to have any chance of finding a support group specifically for people dealing with herpes. For this reason, many turn to the internet for support and this can have mixed results.

There are a lot of memories that can stick in a person’s mind.  Things like your first kiss, that winning touchdown, a big promotion…etc. One of those memories may also include the day the doctor confirmed your herpes diagnosis. Time probably stopped and your ride home seemed like an eternity. Once home, you were scared but the worst part is that you felt isolated and alone.

Like most, you can’t exactly pick up the phone and tell your friends or post it as your Facebook status. More times than not, the stigma of herpes is worst than actually having the virus, itself.  Then, the fear and anxiety set in as you try to ponder what life with herpes will be like. It is times like these where a little support can go a long way.

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Pictures of herpes can be scary!

Don’t worry! Pictures of herpes found on the web are usually worst case scenarios and are not typical!

 

Herpes pictures are some of the first things people tend to search for when they are newly diagnosed or worry they may be infected. Then the panic sets in. What shows up on the web can be horrifying and downright scary! Some look like a flesh-eating disease from a third world country. Don’t freak out because many of the pictures you will come across are probably the very extreme cases of a herpes outbreak.

Important Note – You cannot determine whether or not you have herpes simply by looking at pictures.  Some will look at the images online and think, “My symptoms don’t look like THAT!!!”  Then, they unknowingly pass the herpes virus to their partner.  The only way to know for sure is to get tested.

So, what does herpes actually look like? Under a microscope, HSV1 (Oral) and HSV2 (Genital) look virtual identical. When most people search for pictures of the herpes virus, they usually end up seeing what a worst case outbreak looks like…and they are not pretty!

First, let’s start off by mentioning that the first outbreak is probably the worst. Suppressive medication like Valtrex or Acyclovir can help alleviate the symptoms.  Yes,  it can suck, be painful and the fear can be overwhelming. For most, the symptoms lessen as time goes on. Many of our members report that they have very infrequent outbreaks or have not had any in years.

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GEN-003-trials

GEN-003 is not being marked as a herpes cure quite yet


Genocea’s GEN-003 is not a herpes cure but rather a “Therapeutic Vaccination” for the moment.
Don’t be discouraged because this is a step in the right direction.

In an effort to find a cure for herpes, Genocea has received a lot of attention with its GEN-003 vaccine and clinical trials. At the moment, there seems to be some unwarranted expectations of what they are actually working on. Hopefully, with this update, there will be a better understanding.

First, let’s take “Herpes Cure” off the table for the time being. Genocea cannot market their GEN-003 as a “Cure” to the FDA at this time. It has to be worded carefully. Instead, the vaccination is referred to as a “Therapeutic Vaccination.”

Before we get to what this all means, let’s first explain the stages of a clinical trial for the FDA.  They usually are in 3 stages:

  1. Testing for Safety – This  is always done after testing on animals like mice and guinea pigs. If monkey testing is successful then things look good because their DNA is closest to ours.
  2. Efficacy – A drug (especially vaccination) has to be working at 75% or greater efficacy to go to market. If lower, it goes back to the drawing board. This is done on people with a small testing pool (Say 150) to test the dosage.
  3. The Big Rollout – This is a much wider testing pool of 1000’s of people to test the efficacy. This is used to shore up the data from the efficacy testing in phase 2. This phase is also what determines if it goes to market.

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